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Overall survival at 3 years was lower in the epoetin alfa-treated group compared to control (61% vs.

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Gradual decline in the CD4 lymphocyte count, typically occurring over a period of 10-12 years, culminates in loss of ability to resist opportunistic infections.

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Prior to the availability of human recombinant erythropoietin, patients receiving chronic dialysis treatment frequently required blood transfusions, exposing them to iron overload, viral hepatitis and HIV, and increasing production of antibodies to human antigens which can severely limit transplantation options.

In this open-label trial, we studied 1432 patients with chronic kidney disease, 715 of whom were randomly assigned to receive a dose of epoetin alfa targeted to achieve a hemoglobin level of 13.

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